![]() He received his PhD in molecular physiology and biophysics from. The multiplicity of these pathological events suggest a single therapeutic intervention is unlikely to be successful. Mann, MD, Winters Center for Heart Failure Research, MS 524, 6565 Fannin, Houston, TX 77030. Redwan Huq was an Insight Data Science Fellow (Fall 2017), and currently works in New York City as a Lead Data Scientist at Nielsen. ![]() These data suggest that SCI elicits a wide range of pathological processes within the testes, the actions of which are not restricted to the acute phase of injury but rather extend chronically, potentially through the lifetime of the subject. ![]() At 1.5 years post-SCI, there is a chronic low level immune response as evidenced by an elevation in T cells. This is followed by a subacute initiation of an innate immune response and loss of cell cycle regulation, possibly due to apoptosis within the seminiferous tubules. The testis show an acute drop in normal sexual organ processes, including testosterone production, and establishment of a pro-inflammatory environment. From 24 h, 72 h, 28 days, and 90 days post-SCI, the testis reveal a distinct time course of pathological events. Wood Johnson Medical School, Piscataway, New Jersey 08854 e-mail. Using messenger RNA and metabolomic assessments, we describe molecular and cellular changes that occur within the testis of adult rats over an acute to chronic time period. and Medicine and Howard Hughes Medical Institute, University of Medicine and. ![]() SCI has been shown in humans and rats to induce leukocytospermia, with the presence of inflammatory cytokines, anti-sperm antibodies, and reactive oxygen species found within the ejaculate. We demonstrate that SCI causes measureable pathology in the testis both acutely (24 h) and chronically up to 1.5 years post-injury, leading to loss in sperm motility and viability. In addition to a permanent loss of sensory and motor function, males also will frequently exhibit a profound loss of fertility through poorly understood mechanisms. Houston, Texas MD Candidate at Baylor College of Medicine Hospital & Health Care Education Baylor College of Medicine 2012 - 2016 Doctor of Medicine (M.D.) The University of Texas at Dallas 2008 - 2012 Bachelor of Science (B.S.Spinal cord injury (SCI) results in devastating changes to almost all aspects of a patient's life. ![]()
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